Association between human SHBG gene polymorphisms and risk of PCOS: a meta-analysis

Sex hormone-binding globulin (SHBG) is a plasma glycoprotein that binds androgens and oestrogens, regulates their bioavailability to target tissues. To date, several human SHBG gene polymorphisms have been identified. Polycystic ovary syndrome (PCOS) one of the most common endocrine disorders, hyperandrogenism has considered be hallmark PCOS. Many studies examined association between PCOS risk, but results inconclusive or inconsistent. Therefore, aim this meta-analysis was investigate whether are associated with risk Twelve were included, involving 4733 participants: 2271 patients 2462 control participants. The revealed polymorphism eight more (TAAAA)n pentanucleotide repeats (rs35785886) (odds ratio [OR] = 1.24, 95% confidence interval [CI] 1.06, 1.44, Z 2.77, P 0.006) low serum concentrations in women (standardized mean difference –0.83, CI –1.54, –0.12, 2.30, 0.02). Other (rs6259, rs6257, rs727428 rs1799941) not significantly either concentrations. These findings suggest presence may predictive factor for